The Swiss, a five-time winner at Flushing Meadows, takes on Bulgaria’s Gregor Dimitrov, who has reached the quarterfinals in New York for the first time.

Having dropped the opening set in both of the first two rounds, Federer has been almost faultless in the third and fourth round, cruising past Britain’s Dan Evans 6-2, 6-2, 6-1 and then dispatching Belgium’s David Goffin 6-2, 6-2, 6-0.

The world No. 3 won five U.S. Open titles in a row between 2004 and 2008 but hasn’t tasted success in New York since and hasn’t reached the semifinals since 2015.

That, however, could change this year as Novak Djokovic’s injury has opened the door for either Federer and Rafael Nadal to add to their already bulging trophy cabinets.

The Spaniard made it through to the quarterfinals on Monday night, as he beat 2014 U.S. Open winner Marin Cilic 6-3, 3-6, 6-1, 6-2.

“For some moments in the second set I felt there were too many points in his hands, he was pushing me back, more aggression than me and he hit every ball very strong,” the No. 2 seed said in his post-match press conference.

“After that second set I thought something needs to change or I would be in his hands. I started to return the second serve inside the court and that created a different perspective.”

In the women’s tournament, Williams takes on China’s Wang Qiang. A six-time U.S. Open champion, Williams would equal Margaret Court’s record of 24 Grand Slam singles titles in the Open era.

Should she qualify for the semifinals, the 37-year-old would notch up her 100th win at Flushing Meadows, which would put her just a single win behind Chris Evert’s all-time US Open record of 101.

Naomi Osaka, Williams’ conqueror in last year’s final, was knocked out in the round of 16 on Monday night. The world number 1 lost 7-5, 6-4 to Switzerland’s Belinda Bencic, the No. 13 seed.

“I was so excited to come on the court, the challenge cannot be bigger. Naomi Osaka is a great player and won the US Open last year,” said Bencic. “I had to be on top of my game and am really pleased with how I played.

“She has a lot of power, I was just trying to play it a little bit like chess, anticipate and make a tactic on the court.”

Here’s everything you need to know to keep up with the action on Tuesday.

Quarterfinals start time

The action begins at 12 p.m. at the Arthur Ashe Stadium, when No. 5 seed Elina Svitolina takes on No. 16 seed Johanna Konta, followed by No. 23 seed Stan Wawrinka against No. 5 Daniil Medvedev.

Serena Williams opens up the evening session on center court when she takes on Qiang Wang, while Roger Federer takes on Grigor Dimitrov in the evening session’s final match.

TV channel

The tournament is broadcast exclusively across ESPN channels, with coverage beginning at 12 p.m. and running until 11 p.m. ET on Tuesday on both ESPN and ESPN+.

Live stream

Fans can watch the action online via the WatchESPN app and on ESPN.com and via fuboTV.

Quarterfinals full schedule

The quarterfinals picture will be completed on Wednesday, when Rafael Nadal takes on Argentina’s Diego Schwartzman. The No. 20 seed beat No. 6 Alexander Zverev 3-6, 6-2, 6-4, 6-3 to reach the last eight at Flushing Meadows for the first time since 2017.

The last quarterfinal match sees No. 24 Marco Berrettini play No. 13 Gael Monfils. The Italian crushed Russia’s Andrey Rublev in the round of 16 6-1, 6-4, 7-6 (8-6), while Monfils strolled past Spain’s Pablo Andujar 6-1, 6-2, 6-2.

In the women’s tournament, No. 15 seed Bianca Andreescu plays No. 25 seed Elise Mertens on Wednesday, after the duo dealt a blow to American hopes.

Andreescu beat Taylor Townsend 6-1, 4-6, 6-2, while Mertens cruised past Kristie Ahn 6-1, 6-1.

Having knocked out Naomi Osaka, No. 13 seed Belinda Bencic will play No. 23 Donna Vekic in the quarterfinals after the Croatian beat No. 26 seed Julia Gorges 6-7 (5-7), 7-5, 6-3.

Odds

Novak Djokovic’s injury has shortened the odds on both Rafael Nadal and Roger Federer. According to Oddschecker, the Spaniard is a 9/10 favorite, while the Swiss is at 2/1.

Among the women, Serena Williams is a 13/10 favorite, followed by Bianca Andreescu at 15/4 and Elina Svitolina at 6/1.