Nadal will be trying to match Federer by winning two Grand Slam titles in 2017. Pliskova is seeking her first major championship, while Muguruza will be going for her third after winning the French Open last year.
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The men’s draw will be without ‘16 U.S. Open champion Stan Wawrinka (knee) and two-time winner Novak Djokovic (elbow), who are both out with injuries. On the women’s side, Serena Williams will miss another major while expecting her first child.
Here’s a breakdown of the remaining favorites of both 2017 U.S. Open draws, based on Bovada’s tennis futures as of Aug. 25, with the four best odds bolded in each draw:
U.S. Open tennis 2017: Seeds, odds for men’s draw
Men’s U.S. Open draw, odds
U.S. OPEN DRAW: Federer, Nadal in same half of bracket
Men’s U.S. Open pick
Prediction: Federer has been feeling it for a while, and he has the greater momentum to add to his Grand Slam haul. Cilic really faded hard against him in the Wimbledon final, but the ‘14 U.S. Open champion is the best bet to play spoiler in Flushing Meadows. Nadal and Murray are too inconsistent to trust to go all the way on the hardcourts.
U.S. Open tennis 2017: Seeds, odds for women’s draw
Women’s U.S. Open draw, odds
U.S. OPEN DRAW: Sharapova to face No. 2 seed Halep in first round
Women’s U.S. Open pick
Prediction: Halep got the worst possible first-round matchup against unseeded Maria Sharapova, who is listed at 9-1. Muguruza has yet to advance past the second round a tthe U.S. Open. Venus Williams was extended a bit at Wimbeldon. Kerber is a good defending champ and can win again, but go with Konta to have her overdue major breakthrough after a strong summer.
